NCTF 135HA + microneedling

At SKYN, we pair professional microneedling with NCTF® 135HA, a clinically studied polyrevitalising solution, to support smoother, brighter, healthier-looking skin. NCTF stands for New Cellular Treatment Factor; it’s a powerful treatment as it nourishes from within. Because the solution is delivered through fine micro-channels rather than injected, treatment is comfortable, science-backed, and involves minimal downtime. Every treatment is guided by a personalised, practitioner-led assessment.

Microneedling, clinically known as percutaneous collagen induction, uses fine sterile needles to create thousands of controlled micro-channels in the skin. This prompts the skin’s natural wound-healing response. It activates fibroblasts, the cells responsible for producing collagen, elastin and hyaluronic acid.

NCTF® 135HA, developed in Paris, is a polyrevitalising solution. It is a medical-grade, multi-ingredient treatment made up of non-crosslinked hyaluronic acid with a complex composition of vitamins, amino acids, coenzymes, minerals and nucleic acids, which are the raw materials skin cells use to function, repair and renew. Applied during microneedling, it is delivered directly into the micro-channels as they are created. In effect: microneedling switches the collagen receptors on, and NCTF® 135HA supplies it.

Depending on individual skin characteristics and assessment, NCTF® 135HA + microneedling may be considered for:

• Fine lines and early wrinkles, particularly around the eyes and nasolabial area
• Dull, tired or dehydrated skin
• Enlarged pores and uneven texture
• Mild acne scarring
• Loss of firmness and elasticity

Suitability is assessed on a case-by-case basis during your consultation. The treatment is suitable for all skin types and can be performed on the face, neck, décolletage and hands.

How Microneedling Works

The controlled micro-channels created during treatment trigger the skin’s natural three-phase wound-healing cascade:

1. Inflammation – where growth factors signal the skin to begin repair
2. Proliferation – where fibroblasts are activated and produce fresh Type I and Type III collagen, elastin and glycosaminoglycans
3. Remodelling – where new collagen matures and integrates over the following weeks, progressively firming and smoothing the skin.

The Role of NCTF® 135HA

Used as a topical glide during microneedling, NCTF® 135HA is delivered directly into the micro-channels the needles create. It reaches the level of the skin where fibroblasts are already being activated by the treatment itself, supplying hydration and cell-supporting nutrients exactly where they are needed.

What the Research Shows

NCTF® has been studied for over a decade, in vitro and in clinical trials. In laboratory studies, it significantly increased Type I collagen production by fibroblasts, and in a three-month clinical trial, participants recorded reductions in wrinkle severity and depth alongside measured improvements in skin hydration, tonicity, radiance and pore size. As always, published results reflect study conditions. Individual outcomes vary and no specific result can be guaranteed.

At SKYN, every NCTF® 135HA + microneedling treatment begins with a one-on-one consultation. This ensures your treatment plan is thoughtful, evidence-based, and tailored to your individual skin rather than a one-size-fits-all approach.

During your consultation, your practitioner will:
• Take the time to understand your skin concerns and goals
• Review relevant medical history
• Assess your skin type, condition and suitability
• Recommend a personalised treatment plan and timeframe

A course of three to four sessions, spaced three to four weeks apart, is typically recommended, with maintenance sessions every three to six months depending on individual goals. Treatments start from $400, with your personalised plan and costs confirmed during your consultation.